Publications

Determination of recommended phase II dose of ABTL0812, a novel regulator of Akt/mTOR axis, by pharmacokinetic-pharmacodynamic modelling

J. Alfon L. Vidal L. Gaba I. Victoria M. Gil B. Laquente M. Brunet H. Colom J. Ramis H. Perez-Montoyo M. Cortal M. Gomez-Ferreria P. Muñoz T. Erazo J.M. Lizcano C. Domenech P. Gascon

Published: 11 Oct. 2016

Ann Oncol (2016) 27 (suppl_6): 378P

Background: ABTL0812 is an anticancer agent in clinical development with a novel mechanism of action. It inhibits the Akt/mTOR axis after binding to PPARs and subsequent induction of TRIB3, a pseudokinase that acts as a negative regulator of Akt. Preclinical studies have shown high efficacy in different tumor types including NSCLC, endometrial cancer, pancreatic cancer and neuroblastoma. ABTL0812 exhibits, efficacy in resistant models and synergy with chemotherapy while maintaining extremely low toxicity.

Methods: A phase Ib clinical trial with a 3 + 3 escalation design and an expansion phase was performed in patients with advanced solid tumors. Safety and tolerability were the main objectives of the trial. ABTL0812 pharmacokinetics (PK) was determined and the ratio between phosphorylated Akt and total Akt (pAkt/Akt) levels in...

LATEST NEWS

31.05.2019

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Ability Pharmaceuticals Announces the Presentation of the First Results of ABTL0812 as First Line in Patients with Endometrial or Lung Cancer at 2019 ASCO Annual Meeting + info
04.02.2019

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Ability Pharmaceuticals Announces the Approval in China of a Clinical Study in Pancreatic Cancer with ABTL0812 + info
30.01.2019

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Ability Pharmaceuticals is attending the BIOMED EVENT® by INVEST SECURITIES and the Cholangiocarcinoma Foundation Annual Conference + info
05.12.2018

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AbilityPharma ha superado el millón de euros en la ronda de crowdfunding que abrió el pasado mes de septiembre + info
07.11.2018

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Ability Pharmaceuticals Announces FDA-Orphan Drug Designation for ABTL0812 in Biliary Tract Cancer + info
19.09.2018

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Ability Pharmaceuticals anuncia la inclusión del primer paciente en el estudio clínico de la fase 2 de ABTL0812 en Francia + info
24.08.2018

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At AbilityPharma we are very pleased to announce the start of a crowdfunding campaign through de Capital Cell + info
19.02.2018

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AbilityPharma Announces FDA Approval of Phase 1/2 Trial of ABTL0812 for Patients with Advanced Metastatic Pancreatic Cancer + info
13.12.2017

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AbilityPharma Announces FDA Approval of IND for Phase 2 Trial of ABTL0812 in Patients with Endometrial Cancer or Squamous Non-Small Cell Lung Cancer + info
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